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nitrofurantoin facts at Drugs.com

nitrofurantoin is used for:

Based on urinary pharmacokinetic data, the extent and rate of urinary excretion of nitrofurantoin from the 100 mg Macrobid capsule are similar to those of the 50 mg or 100 mg Macrodantin® (nitrofurantoin macrocrystals) capsule. Twenty-five percent is macrocrystalline nitrofurantoin, which has slower dissolution and absorption than nitrofurantoin monohydrate. These acute reactions usually occur within the first week of treatment and subside when therapy with nitrofurantoin is stopped. {37} Also, nitrofurantoin is ineffective in patients whose creatinine clearance is less than 40 mL per minute. The Macrobid® brand of nitrofurantoin is a hard gelatin capsule shell containing the equivalent of 100 mg of nitrofurantoin in the form of 25 mg of nitrofurantoin macrocrystals and 75 mg of nitrofurantoin monohydrate. Chronic pulmonary reactions, including diffuse interstitial pneumonitis and fibrosis, are insidious in onset and are more likely to occur in patients who have been on nitrofurantoin therapy for at least 6 months.

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